We study the molecular mechanisms underlying membrane protein biogenesis and quality control using biochemical, structural and cell biology approaches.
UCSF
San Francisco, CA
Postdoc - Biochemistry and Biophysics
1999
UCSF
San Francisco, CA
PHD - Biochemistry and Biophysics
1998
Bates College
Lewiston, ME
BS - Biology and Chemistry
1990
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification. Cell. 2025 Jan 23; 188(2):465-483.e22.
PMID: 39579764
The prolyl isomerase FKBP11 is a secretory translocon accessory factor.
The prolyl isomerase FKBP11 is a secretory translocon accessory factor. Mol Biol Cell. 2024 Nov 01; 35(11):ar135.
PMID: 39259761
Structural analysis of the dynamic ribosome-translocon complex.
Structural analysis of the dynamic ribosome-translocon complex. Elife. 2024 Jun 18; 13.
PMID: 38896445
A unifying model for membrane protein biogenesis.
A unifying model for membrane protein biogenesis. Nat Struct Mol Biol. 2024 Jul; 31(7):1009-1017.
PMID: 38811793
Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center.
Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center. J Racial Ethn Health Disparities. 2025 Feb; 12(1):107-117.
PMID: 37917235
Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake.
Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake. Cancer Med. 2023 09; 12(18):19033-19046.
PMID: 37596773
Mechanism of an intramembrane chaperone for multipass membrane proteins.
Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature. 2022 11; 611(7934):161-166.
PMID: 36261528
Substrate-driven assembly of a translocon for multipass membrane proteins.
Substrate-driven assembly of a translocon for multipass membrane proteins. Nature. 2022 11; 611(7934):167-172.
PMID: 36261522
Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida.
Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida. JAMA Oncol. 2022 05 01; 8(5):748-754.
PMID: 35266953
The mechanisms of integral membrane protein biogenesis.
The mechanisms of integral membrane protein biogenesis. Nat Rev Mol Cell Biol. 2022 02; 23(2):107-124.
PMID: 34556847