We study the molecular mechanisms underlying membrane protein biogenesis and quality control using biochemical, structural and cell biology approaches.
UCSF
San Francisco, CA
Postdoc - Biochemistry and Biophysics
1999
UCSF
San Francisco, CA
PHD - Biochemistry and Biophysics
1998
Bates College
Lewiston, ME
BS - Biology and Chemistry
1990
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification. Cell. 2025 Jan 23; 188(2):465-483.e22.
PMID: 39579764
The prolyl isomerase FKBP11 is a secretory translocon accessory factor.
The prolyl isomerase FKBP11 is a secretory translocon accessory factor. Mol Biol Cell. 2024 Nov 01; 35(11):ar135.
PMID: 39259761
Recurrence of Non-Small Cell Lung Cancer With Visceral Pleural Invasion: A Secondary Analysis of a Randomized Clinical Trial.
Recurrence of Non-Small Cell Lung Cancer With Visceral Pleural Invasion: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2024 Sep 01; 10(9):1179-1186.
PMID: 39088196
Structural analysis of the dynamic ribosome-translocon complex.
Structural analysis of the dynamic ribosome-translocon complex. Elife. 2024 Jun 18; 13.
PMID: 38896445
A unifying model for membrane protein biogenesis.
A unifying model for membrane protein biogenesis. Nat Struct Mol Biol. 2024 Jul; 31(7):1009-1017.
PMID: 38811793
Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center.
Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center. J Racial Ethn Health Disparities. 2025 Feb; 12(1):107-117.
PMID: 37917235
Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake.
Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake. Cancer Med. 2023 09; 12(18):19033-19046.
PMID: 37596773
Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer.
Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer. N Engl J Med. 2023 02 09; 388(6):489-498.
PMID: 36780674
Mechanism of an intramembrane chaperone for multipass membrane proteins.
Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature. 2022 11; 611(7934):161-166.
PMID: 36261528
Substrate-driven assembly of a translocon for multipass membrane proteins.
Substrate-driven assembly of a translocon for multipass membrane proteins. Nature. 2022 11; 611(7934):167-172.
PMID: 36261522