A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila. PLoS Genet. 2022 05; 18(5):e1010194. View in: PubMed
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun. 2022 04 05; 13(1):1833. View in: PubMed
Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature. 2021 12; 600(7888):334-338. View in: PubMed
Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat Struct Mol Biol. 2021 07; 28(7):614-625. View in: PubMed
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. Nat Chem Biol. 2021 08; 17(8):896-905. View in: PubMed
Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat Commun. 2021 01 05; 12(1):121. View in: PubMed
Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states. Structure. 2021 07 01; 29(7):709-720.e3. View in: PubMed
Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism. Nat Commun. 2020 05 01; 11(1):2140. View in: PubMed
Structural basis for adhesion G protein-coupled receptor Gpr126 function. Nat Commun. 2020 01 10; 11(1):194. View in: PubMed
Structural principles of SNARE complex recognition by the AAA+ protein NSF. Elife. 2018 09 10; 7. View in: PubMed
Stem cell heterogeneity drives the parasitic life cycle of Schistosoma mansoni. Elife. 2018 07 10; 7. View in: PubMed
NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin. Elife. 2018 07 09; 7. View in: PubMed
Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nat Struct Mol Biol. 2018 04; 25(4):341-346. View in: PubMed
The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature. 2017 08 24; 548(7668):420-425. View in: PubMed
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18. Neuron. 2017 Aug 02; 95(3):591-607.e10. View in: PubMed
Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex. Elife. 2016 10 12; 5. View in: PubMed
N-terminal domain of complexin independently activates calcium-triggered fusion. Proc Natl Acad Sci U S A. 2016 08 09; 113(32):E4698-707. View in: PubMed
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex. Elife. 2016 06 02; 5. View in: PubMed
Recent Advances in Deciphering the Structure and Molecular Mechanism of the AAA+ ATPase N-Ethylmaleimide-Sensitive Factor (NSF). J Mol Biol. 2016 05 08; 428(9 Pt B):1912-26. View in: PubMed