Joseph A. Piccirilli, PhD

Structural basis for promiscuity in ligand recognition by yjdF riboswitch.
Structural basis for promiscuity in ligand recognition by yjdF riboswitch. Cell Discov. 2024 Apr 02; 10(1):37.
PMID: 38565535

Structure-guided aminoacylation and assembly of chimeric RNAs.
Structure-guided aminoacylation and assembly of chimeric RNAs. bioRxiv. 2024 Mar 03.
PMID: 38464152

Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology.
Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology. bioRxiv. 2023 Dec 10.
PMID: 38106193

Genome-Wide Profiling of tRNA Using an Unexplored Reverse Transcriptase with High Processivity.
Genome-Wide Profiling of tRNA Using an Unexplored Reverse Transcriptase with High Processivity. bioRxiv. 2023 Dec 09.
PMID: 38106225

Crystal structure of a cap-independent translation enhancer RNA.
Crystal structure of a cap-independent translation enhancer RNA. Nucleic Acids Res. 2023 09 08; 51(16):8891-8907.
PMID: 37548413

Reinvestigating the Synthesis and Characterization of Ethyl 3-[5-(2-Ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]-but-2-enoate.
Reinvestigating the Synthesis and Characterization of Ethyl 3-[5-(2-Ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]-but-2-enoate. ACS Omega. 2023 Sep 05; 8(35):31941-31945.
PMID: 37692243

Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.
Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis. Biochemistry. 2023 07 04; 62(13):2079-2092.
PMID: 37294744

A general and efficient approach to synthesize the phosphoramidites of 5'-18O labeled purine nucleosides.
A general and efficient approach to synthesize the phosphoramidites of 5'-18O labeled purine nucleosides. Nucleosides Nucleotides Nucleic Acids. 2023; 42(11):930-943.
PMID: 37233721

Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.
Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis. J Am Chem Soc. 2023 02 08; 145(5):2830-2839.
PMID: 36706353

Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5'-methylene substituted 2',5'-deoxyribonucleotides.
Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5'-methylene substituted 2',5'-deoxyribonucleotides. Nucleosides Nucleotides Nucleic Acids. 2023; 42(7):538-546.
PMID: 36629008

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