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Francisco Bezanilla

Professor
fbezanilla@uchicago.edu
Biosciences Graduate Program Association
Publications

  1. Noncanonical electromechanical coupling paths in cardiac hERG potassium channel. Nat Commun. 2023 02 27; 14(1):1110. View in: PubMed

  2. Ion channel thermodynamics studied with temperature jumps measured at the cell membrane. Biophys J. 2023 02 21; 122(4):661-671. View in: PubMed

  3. Optocapacitance: physical basis and its application. Biophys Rev. 2022 Apr; 14(2):569-577. View in: PubMed

  4. Tracking the movement of discrete gating charges in a voltage-gated potassium channel. Elife. 2021 11 15; 10. View in: PubMed

  5. Gating current noise produced by Brownian models of a voltage sensor. Biophys J. 2021 09 21; 120(18):3983-4001. View in: PubMed

  6. Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels. Elife. 2021 02 23; 10. View in: PubMed

  7. Transient Electrical Currents Mediated by the Na+/K+-ATPase: A Tour from Basic Biophysics to Human Diseases. Biophys J. 2020 07 21; 119(2):236-242. View in: PubMed

  8. Remote nongenetic optical modulation of neuronal activity using fuzzy graphene. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13339-13349. View in: PubMed

  9. Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):6023-6034. View in: PubMed

  10. Metal Bridge in S4 Segment Supports Helix Transition in Shaker Channel. Biophys J. 2020 02 25; 118(4):922-933. View in: PubMed

  11. Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers?of Shaker. Nat Commun. 2019 08 08; 10(1):3584. View in: PubMed

  12. An atlas of nano-enabled neural interfaces. Nat Nanotechnol. 2019 07; 14(7):645-657. View in: PubMed

  13. Nongenetic optical neuromodulation with silicon-based materials. Nat Protoc. 2019 05; 14(5):1339-1376. View in: PubMed

  14. Continuum Gating Current Models Computed with?Consistent Interactions. Biophys J. 2019 01 22; 116(2):270-282. View in: PubMed

  15. Methodological improvements for fluorescence recordings in Xenopus laevis oocytes. J Gen Physiol. 2019 02 04; 151(2):264-272. View in: PubMed

  16. Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity. ACS Chem Neurosci. 2019 03 20; 10(3):1478-1487. View in: PubMed

  17. Influences: The Cell Physiology Laboratory in Montemar, Chile. J Gen Physiol. 2018 11 05; 150(11):1464-1468. View in: PubMed

  18. Gating currents. J Gen Physiol. 2018 07 02; 150(7):911-932. View in: PubMed

  19. Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape. J Gen Physiol. 2018 07 02; 150(7):1017-1024. View in: PubMed

  20. Determination of the Stoichiometry between a- and ?1 Subunits of the BK Channel Using LRET. Biophys J. 2018 06 05; 114(11):2493-2497. View in: PubMed

  21. Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires. Nat Nanotechnol. 2018 03; 13(3):260-266. View in: PubMed

  22. Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation. Sci Rep. 2018 02 02; 8(1):2207. View in: PubMed

  23. Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep. 2018 01 12; 8(1):607. View in: PubMed

  24. Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels. J Gen Physiol. 2018 02 05; 150(2):307-321. View in: PubMed

  25. LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b. Biophys J. 2018 01 09; 114(1):88-97. View in: PubMed

  26. Optocapacitive Generation of Action Potentials by Microsecond Laser Pulses of Nanojoule Energy. Biophys J. 2018 01 23; 114(2):283-288. View in: PubMed

  27. Roadmap on semiconductor-cell biointerfaces. Phys Biol. 2018 03 09; 15(3):031002. View in: PubMed

  28. Nav channel binder containing a specific conjugation-site based on a low toxicity ?-scorpion toxin. Sci Rep. 2017 11 27; 7(1):16329. View in: PubMed

  29. Correspondence: Reply to 'Revisiting the theoretical cell membrane thermal capacitance response'. Nat Commun. 2017 11 10; 8(1):1432. View in: PubMed

  30. Corrigendum: Infrared light excites cells by changing their electrical capacitance. Nat Commun. 2017 11 10; 8:16148. View in: PubMed

  31. Biophysical Characterization of Genetically Encoded Voltage Sensor ASAP1: Dynamic Range Improvement. Biophys J. 2017 Nov 21; 113(10):2178-2181. View in: PubMed

  32. Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit. Sci Rep. 2017 03 28; 7:45310. View in: PubMed

  33. Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):E1857-E1865. View in: PubMed

  34. Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin. Angew Chem Int Ed Engl. 2017 03 13; 56(12):3324-3328. View in: PubMed

  35. A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor. Biophys J. 2016 Oct 04; 111(7):1396-1408. View in: PubMed

  36. Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces. Nat Mater. 2016 09; 15(9):1023-30. View in: PubMed

  37. Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin. Angew Chem Int Ed Engl. 2016 07 18; 55(30):8639-42. View in: PubMed

  38. ?1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3231-9. View in: PubMed

  39. Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nat Commun. 2015 Dec 17; 6:10173. View in: PubMed

  40. Single-molecule fluorimetry and gating currents inspire an improved optical voltage indicator. Elife. 2015 Nov 24; 4:e10482. View in: PubMed

  41. Resting state of the human proton channel dimer in a lipid bilayer. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):E5926-35. View in: PubMed

  42. Functional Site-Directed Fluorometry. Adv Exp Med Biol. 2015; 869:55-76. View in: PubMed

  43. Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase. Nat Commun. 2015 Jul 24; 6:7622. View in: PubMed

  44. Photosensitivity of neurons enabled by cell-targeted gold nanoparticles. Neuron. 2015 Apr 08; 86(1):207-17. View in: PubMed

  45. A structural rearrangement of the Na+/K+-ATPase traps ouabain within the external ion permeation pathway. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1335-1344. View in: PubMed

  46. Real-time imaging of electrical signals with an infrared FDA-approved dye. Biophys J. 2014 Sep 16; 107(6):L09-12. View in: PubMed

  47. Probing a-3(10) transitions in a voltage-sensing S4 helix. Biophys J. 2014 Sep 02; 107(5):1117-1128. View in: PubMed

  48. Total chemical synthesis of biologically active fluorescent dye-labeled Ts1 toxin. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8970-4. View in: PubMed

  49. Moving gating charges through the gating pore in a Kv channel voltage sensor. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):E1950-9. View in: PubMed

  50. Molecular mechanism of Mg2+-dependent gating in CorA. Nat Commun. 2014 Apr 02; 5:3590. View in: PubMed

  51. A repulsion mechanism explains magnesium permeation and selectivity in CorA. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3002-7. View in: PubMed

  52. S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel. Biophys J. 2013 Nov 19; 105(10):2312-22. View in: PubMed

  53. The gating charge should not be estimated by fitting a two-state model to a Q-V curve. J Gen Physiol. 2013 Dec; 142(6):575-8. View in: PubMed

  54. Sensing charges of the Ciona intestinalis voltage-sensing phosphatase. J Gen Physiol. 2013 Nov; 142(5):543-55. View in: PubMed

  55. Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation. Neuron. 2013 Aug 21; 79(4):651-7. View in: PubMed

  56. Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography. J Am Chem Soc. 2013 Aug 14; 135(32):11911-9. View in: PubMed

  57. Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels. J Gen Physiol. 2013 Aug; 142(2):101-12. View in: PubMed

  58. Thermal mechanisms of millimeter wave stimulation of excitable cells. Biophys J. 2013 Jun 18; 104(12):2622-8. View in: PubMed

  59. IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):E559-66. View in: PubMed

  60. Intermediate state trapping of a voltage sensor. J Gen Physiol. 2012 Dec; 140(6):635-52. View in: PubMed

  61. An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol. 2012 Dec; 140(6):587-94. View in: PubMed

  62. Molecular mechanism for depolarization-induced modulation of Kv channel closure. J Gen Physiol. 2012 Nov; 140(5):481-93. View in: PubMed

  63. Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations. Structure. 2012 Oct 10; 20(10):1629-40. View in: PubMed

  64. Tuning the voltage-sensor motion with a single residue. Biophys J. 2012 Aug 08; 103(3):L23-L25. View in: PubMed

  65. Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain. Biophys J. 2012 Mar 21; 102(6):1372-82. View in: PubMed

  66. Infrared light excites cells by changing their electrical capacitance. Nat Commun. 2012 Mar 13; 3:736. View in: PubMed

  67. The dynamic relationships between the three events that release individual Na? ions from the Na?/K?-ATPase. Nat Commun. 2012 Feb 14; 3:669. View in: PubMed

  68. Depolarization induces a conformational change in the binding site region of the M2 muscarinic receptor. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):285-90. View in: PubMed

  69. In search of a consensus model of the resting state of a voltage-sensing domain. Neuron. 2011 Dec 08; 72(5):713-20. View in: PubMed

  70. Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20556-61. View in: PubMed

  71. Ouabain binding site in a functioning Na+/K+ ATPase. J Biol Chem. 2011 Nov 04; 286(44):38177-38183. View in: PubMed

  72. Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6444-9. View in: PubMed

  73. Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential. J Biol Chem. 2011 May 20; 286(20):17945-53. View in: PubMed

  74. Properties of deactivation gating currents in Shaker channels. Biophys J. 2011 Mar 02; 100(5):L28-30. View in: PubMed

  75. The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers. J Gen Physiol. 2010 Nov; 136(5):555-68. View in: PubMed

  76. Gating currents from neuronal K(V)7.4 channels: general features and correlation with the ionic conductance. Channels (Austin). 2009 Jul-Aug; 3(4):274-83. View in: PubMed

  77. Coupling between the voltage-sensing and phosphatase domains of Ci-VSP. J Gen Physiol. 2009 Jul; 134(1):5-14. View in: PubMed

  78. A single charged voltage sensor is capable of gating the Shaker K+ channel. J Gen Physiol. 2009 May; 133(5):467-83. View in: PubMed

  79. Trade-off between aerobic capacity and locomotor capability in an Antarctic pteropod. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6192-6. View in: PubMed

  80. Charge movement of a voltage-sensitive fluorescent protein. Biophys J. 2009 Jan; 96(2):L19-21. View in: PubMed

  81. Fluorescence detection of the movement of single KcsA subunits reveals cooperativity. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20263-8. View in: PubMed

  82. Ion channels: from conductance to structure. Neuron. 2008 Nov 06; 60(3):456-68. View in: PubMed

  83. S4-based voltage sensors have three major conformations. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17600-7. View in: PubMed

  84. Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels. J Gen Physiol. 2008 Aug; 132(2):251-63. View in: PubMed

  85. How membrane proteins sense voltage. Nat Rev Mol Cell Biol. 2008 Apr; 9(4):323-32. View in: PubMed

  86. A common pathway for charge transport through voltage-sensing domains. Neuron. 2008 Feb 07; 57(3):345-51. View in: PubMed

  87. In vivo measurement of intramolecular distances using genetically encoded reporters. Biophys J. 2007 Nov 01; 93(9):L45-7. View in: PubMed

  88. beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel. J Gen Physiol. 2007 Sep; 130(3):257-68. View in: PubMed

  89. Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7904-9. View in: PubMed

  90. The action potential: from voltage-gated conductances to molecular structures. Biol Res. 2006; 39(3):425-35. View in: PubMed

  91. Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor. Nature. 2006 Nov 02; 444(7115):106-9. View in: PubMed

  92. Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15865-70. View in: PubMed

  93. Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. J Gen Physiol. 2006 Nov; 128(5):569-81. View in: PubMed

  94. Analysis of the optimal channel density of the squid giant axon using a reparameterized Hodgkin-Huxley model. J Neurophysiol. 2006 Aug; 96(2):959; author reply 960. View in: PubMed

  95. Optical detection of rate-determining ion-modulated conformational changes of the ether-?-go-go K+ channel voltage sensor. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18718-23. View in: PubMed

  96. A hybrid approach to measuring electrical activity in genetically specified neurons. Nat Neurosci. 2005 Nov; 8(11):1619-26. View in: PubMed

  97. Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature. 2005 Aug 11; 436(7052):852-6. View in: PubMed

  98. Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer. Nature. 2005 Aug 11; 436(7052):848-51. View in: PubMed

  99. The origin of subconductance levels in voltage-gated K+ channels. J Gen Physiol. 2005 Aug; 126(2):83-6. View in: PubMed

  100. The voltage-sensor structure in a voltage-gated channel. Trends Biochem Sci. 2005 Apr; 30(4):166-8. View in: PubMed

  101. Voltage-gated ion channels. IEEE Trans Nanobioscience. 2005 Mar; 4(1):34-48. View in: PubMed

  102. Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter. J Gen Physiol. 2005 Jan; 125(1):13-36. View in: PubMed

  103. Silicon chip-based patch-clamp electrodes integrated with PDMS microfluidics. Biosens Bioelectron. 2004 Oct 15; 20(3):509-17. View in: PubMed

  104. RNA editing of a human potassium channel modifies its inactivation. Nat Struct Mol Biol. 2004 Oct; 11(10):915-6. View in: PubMed

  105. Gating of the bacterial sodium channel, NaChBac: voltage-dependent charge movement and gating currents. J Gen Physiol. 2004 Oct; 124(4):349-56. View in: PubMed

  106. A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10195-200. View in: PubMed

  107. Detecting rearrangements of shaker and NaChBac in real-time with fluorescence spectroscopy in patch-clamped mammalian cells. Biophys J. 2004 Jun; 86(6):3966-80. View in: PubMed

  108. Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements. J Gen Physiol. 2004 Mar; 123(3):217-30. View in: PubMed

  109. A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature. 2004 Feb 05; 427(6974):548-53. View in: PubMed

  110. Fast gating in the Shaker K+ channel and the energy landscape of activation. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7611-5. View in: PubMed

  111. A physical model of potassium channel activation: from energy landscape to gating kinetics. Biophys J. 2003 Jun; 84(6):3703-16. View in: PubMed

  112. The voltage sensor and the gate in ion channels. Adv Protein Chem. 2003; 63:211-41. View in: PubMed

  113. A fluorometric approach to local electric field measurements in a voltage-gated ion channel. Neuron. 2003 Jan 09; 37(1):85-97. View in: PubMed

  114. Structural biology. Force and voltage sensors in one structure. Science. 2002 Nov 22; 298(5598):1562-3. View in: PubMed

  115. Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation. J Gen Physiol. 2002 Nov; 120(5):629-45. View in: PubMed

  116. Voltage sensor movements. J Gen Physiol. 2002 Oct; 120(4):465-73. View in: PubMed

  117. Extensive editing of mRNAs for the squid delayed rectifier K+ channel regulates subunit tetramerization. Neuron. 2002 May 30; 34(5):743-57. View in: PubMed

  118. A comparison of propagated action potentials from tropical and temperate squid axons: different durations and conduction velocities correlate with ionic conductance levels. J Exp Biol. 2002 Jun; 205(Pt 12):1819-30. View in: PubMed

  119. Charge translocation by the Na/K pump. Ann N Y Acad Sci. 1997 Nov 03; 834:231-43. View in: PubMed

  120. Twitches in the presence of ethylene glycol bis( -aminoethyl ether)-N,N'-tetracetic acid. Biochim Biophys Acta. 1972 Jun 23; 267(3):605-8. View in: PubMed
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