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Erin J. Adams

Professor
ejadams@uchicago.edu
Websites
Research Summary
Our laboratory is interested in the molecular signals that are used by the immune system to distinguish healthy from unhealthy tissue. Many of our projects focus on “unconventional” T cell recognition, involving ?d T cells, Natural Killer T cells and Muscosal-Associated Invariant T (MAIT) cells and antigen presentation by nonclassical or MHC-like proteins. Our strengths are in biochemistry, structural biology, protein engineering and cellular assays that will reveal the fundamental principles behind how effector cells of the immune system regulate human disease. We have a high level of expertise in studying molecular recognition of T cells, particularly unconventional T cells outside the canonical CD4+/CD8+ lineage and structure function of antigen-presenting molecules.
Keywords
Molecular Immunology, T Cells, MHC (nonclassical and MHC-like), biochemistry, structural biology
Education
  • UC San Diego, La Jolla, CA, BS Animal Physiology and Neuroscience 06/1993
  • UC Berkeley, Berkeley, CA, PhD Evolutionary Genetics 06/2001
  • Stanford University, Stanford, CA, Postdoc Molecular Immunology 10/2005
Biosciences Graduate Program Association
Awards & Honors
  • 1993 - Graduate Cum Laude UC San Diego
  • 1993 - Phi Beta Kappa UC San Diego
  • 2001 - 2004 Cancer Research Institute Postdoc Fellow Stanford University
  • 2007 - 2010 Searle Scholar UChicago
  • 2016 - pres Joseph Regenstein Professorship UChicago
Publications

  1. Borowska MT, Drees C, Yarawsky AE, Viswanathan M, Ryan SM, Bunker JJ, Herr AB, Bendelac A, Adams EJ. The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proc Natl Acad Sci U S A. 2021 09 28; 118(39). View in: PubMed

  2. Kerr D, Gong Z, Suwatthee T, Luoma A, Roy S, Scarpaci R, Hwang HL, Henderson JM, Cao KD, Bu W, Lin B, Tietjen GT, Steck TL, Adams EJ, Lee KYC. How Tim proteins differentially exploit membrane features to attain robust target sensitivity. Biophys J. 2021 Sep 14. View in: PubMed

  3. Mallis RJ, Duke-Cohan JS, Das DK, Akitsu A, Luoma AM, Banik D, Stephens HM, Tetteh PW, Castro CD, Krahnke S, Hussey RE, Lawney B, Brazin KN, Reche PA, Hwang W, Adams EJ, Lang MJ, Reinherz EL. Molecular design of the ?dT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing. Proc Natl Acad Sci U S A. 2021 Jun 29; 118(26). View in: PubMed

  4. Klawon DEJ, Gilmore DC, Leonard JD, Miller CH, Chao JL, Walker MT, Duncombe RK, Tung KS, Adams EJ, Savage PA. Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration. J Exp Med. 2021 06 07; 218(6). View in: PubMed

  5. Boughter CT, Borowska MT, Guthmiller JJ, Bendelac A, Wilson PC, Roux B, Adams EJ. Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops. Elife. 2020 11 10; 9. View in: PubMed

  6. Castro CD, Boughter CT, Broughton AE, Ramesh A, Adams EJ. Diversity in recognition and function of human ?d T cells. Immunol Rev. 2020 11; 298(1):134-152. View in: PubMed

  7. Fichtner AS, Karunakaran MM, Gu S, Boughter CT, Borowska MT, Starick L, Nöhren A, Göbel TW, Adams EJ, Herrmann T. Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive V?9Vd2 T cell subset. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6697-6707. View in: PubMed

  8. Ladd NA, Froyd CA, Adams EJ. Production of MR1 Tetramers Loaded with Microbial Ligands. Methods Mol Biol. 2020; 2098:191-207. View in: PubMed

  9. Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Science. 2019 10 25; 366(6464). View in: PubMed

  10. Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J. TCR-pMHC bond conformation controls TCR ligand discrimination. Cell Mol Immunol. 2020 03; 17(3):203-217. View in: PubMed

  11. D'Souza MP, Adams E, Altman JD, Birnbaum ME, Boggiano C, Casorati G, Chien YH, Conley A, Eckle SBG, Früh K, Gondré-Lewis T, Hassan N, Huang H, Jayashankar L, Kasmar AG, Kunwar N, Lavelle J, Lewinsohn DM, Moody B, Picker L, Ramachandra L, Shastri N, Parham P, McMichael AJ, Yewdell JW. Casting a wider net: Immunosurveillance by nonclassical MHC molecules. PLoS Pathog. 2019 02; 15(2):e1007567. View in: PubMed

  12. Benveniste PM, Roy S, Nakatsugawa M, Chen ELY, Nguyen L, Millar DG, Ohashi PS, Hirano N, Adams EJ, Zúñiga-Pflücker JC. Generation and molecular recognition of melanoma-associated antigen-specific human ?d T cells. Sci Immunol. 2018 12 14; 3(30). View in: PubMed

  13. Crooks JE, Boughter CT, Scott LR, Adams EJ. The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution. Front Mol Biosci. 2018; 5:95. View in: PubMed

  14. Harriff MJ, McMurtrey C, Froyd CA, Jin H, Cansler M, Null M, Worley A, Meermeier EW, Swarbrick G, Nilsen A, Lewinsohn DA, Hildebrand W, Adams EJ, Lewinsohn DM. MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage. Sci Immunol. 2018 07 13; 3(25). View in: PubMed

  15. Kerr D, Tietjen GT, Gong Z, Tajkhorshid E, Adams EJ, Lee KYC. Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins. Biochim Biophys Acta Biomembr. 2018 10; 1860(10):2126-2133. View in: PubMed

  16. Gu S, Borowska MT, Boughter CT, Adams EJ. Butyrophilin3A proteins and V?9Vd2 T cell activation. Semin Cell Dev Biol. 2018 12; 84:65-74. View in: PubMed

  17. Parameswaran R, Carvalho-de-Souza JL, Jiang Y, Burke MJ, Zimmerman JF, Koehler K, Phillips AW, Yi J, Adams EJ, Bezanilla F, Tian B. Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires. Nat Nanotechnol. 2018 03; 13(3):260-266. View in: PubMed

  18. Tietjen GT, Baylon JL, Kerr D, Gong Z, Henderson JM, Heffern CTR, Meron M, Lin B, Schlossman ML, Adams EJ, Tajkhorshid E, Lee KYC. Coupling X-Ray Reflectivity and In Silico Binding to Yield Dynamics of Membrane Recognition by Tim1. Biophys J. 2017 Oct 03; 113(7):1505-1519. View in: PubMed

  19. Gu S, Sachleben JR, Boughter CT, Nawrocka WI, Borowska MT, Tarrasch JT, Skiniotis G, Roux B, Adams EJ. Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V?9Vd2 T cell activation. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):E7311-E7320. View in: PubMed

  20. Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA. Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen. Immunity. 2017 07 18; 47(1):107-117.e8. View in: PubMed

  21. Moulin M, Alguacil J, Gu S, Mehtougui A, Adams EJ, Peyrottes S, Champagne E. V?9Vd2 T cell activation by strongly agonistic nucleotidic phosphoantigens. Cell Mol Life Sci. 2017 12; 74(23):4353-4367. View in: PubMed

  22. Dulberger CL, McMurtrey CP, Hölzemer A, Neu KE, Liu V, Steinbach AM, Garcia-Beltran WF, Sulak M, Jabri B, Lynch VJ, Altfeld M, Hildebrand WH, Adams EJ. Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors. Immunity. 2017 06 20; 46(6):1018-1029.e7. View in: PubMed

  23. Mattarei A, Enzinger M, Gu S, Karunakaran MM, Kimmel B, Berner N, Adams EJ, Herrmann T, Amslinger S. A Photo-Crosslinkable Biotin Derivative of the Phosphoantigen (E)-4-Hydroxy-3-Methylbut-2-Enyl Diphosphate (HMBPP) Activates V?9Vd2 T Cells and Binds to the HMBPP Site of BTN3A1. Chemistry. 2017 Sep 04; 23(49):11945-11954. View in: PubMed

  24. Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS, Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G, Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, Picker LJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB. MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates. Mucosal Immunol. 2017 05; 10(3):802-813. View in: PubMed

  25. Sebestyen Z, Scheper W, Vyborova A, Gu S, Rychnavska Z, Schiffler M, Cleven A, Chéneau C, van Noorden M, Peigné CM, Olive D, Lebbink RJ, Oostvogels R, Mutis T, Schuurhuis GJ, Adams EJ, Scotet E, Kuball J. RhoB Mediates Phosphoantigen Recognition by V?9Vd2 T Cell Receptor. Cell Rep. 2016 05 31; 15(9):1973-85. View in: PubMed

  26. Roy S, Ly D, Castro CD, Li NS, Hawk AJ, Altman JD, Meredith SC, Piccirilli JA, Moody DB, Adams EJ. Molecular Analysis of Lipid-Reactive Vd1 ?d T Cells Identified by CD1c Tetramers. J Immunol. 2016 Feb 15; 196(4):1933-42. View in: PubMed

  27. Castro CD, Luoma AM, Adams EJ. Coevolution of T-cell receptors with MHC and non-MHC ligands. Immunol Rev. 2015 Sep; 267(1):30-55. View in: PubMed

  28. Napier RJ, Adams EJ, Gold MC, Lewinsohn DM. The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity. Front Immunol. 2015; 6:344. View in: PubMed

  29. Adams EJ, Havran WL. Introduction to Cellular Immunology Special Issue on ?d T cells. Cell Immunol. 2015 Jul; 296(1):1-2. View in: PubMed

  30. Adams EJ, Gu S, Luoma AM. Human gamma delta T cells: Evolution and ligand recognition. Cell Immunol. 2015 Jul; 296(1):31-40. View in: PubMed

  31. Gu S, Nawrocka W, Adams EJ. Sensing of Pyrophosphate Metabolites by V?9Vd2 T Cells. Front Immunol. 2014; 5:688. View in: PubMed

  32. Roy S, Ly D, Li NS, Altman JD, Piccirilli JA, Moody DB, Adams EJ. Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by aß T cells. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):E4648-57. View in: PubMed

  33. Luoma AM, Castro CD, Adams EJ. ?d T cell surveillance via CD1 molecules. Trends Immunol. 2014 12; 35(12):613-621. View in: PubMed

  34. Meyer A, Carapito R, Ott L, Radosavljevic M, Georgel P, Adams EJ, Parham P, Bontrop RE, Blancher A, Bahram S. High diversity of MIC genes in non-human primates. Immunogenetics. 2014 Oct; 66(9-10):581-7. View in: PubMed

  35. Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WWA. The CD3 conformational change in the ?d T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing. Cell Rep. 2014 Jun 12; 7(5):1704-1715. View in: PubMed

  36. Tietjen GT, Gong Z, Chen CH, Vargas E, Crooks JE, Cao KD, Heffern CT, Henderson JM, Meron M, Lin B, Roux B, Schlossman ML, Steck TL, Lee KY, Adams EJ. Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):E1463-72. View in: PubMed

  37. Sandstrom A, Peigné CM, Léger A, Crooks JE, Konczak F, Gesnel MC, Breathnach R, Bonneville M, Scotet E, Adams EJ. The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V?9Vd2 T cells. Immunity. 2014 Apr 17; 40(4):490-500. View in: PubMed

  38. Adams EJ. Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them. Curr Opin Immunol. 2014 Feb; 26:1-6. View in: PubMed

  39. Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal structure of Vd1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human ?d T cells. Immunity. 2013 Dec 12; 39(6):1032-42. View in: PubMed

  40. López-Sagaseta J, Dulberger CL, McFedries A, Cushman M, Saghatelian A, Adams EJ. MAIT recognition of a stimulatory bacterial antigen bound to MR1. J Immunol. 2013 Nov 15; 191(10):5268-77. View in: PubMed

  41. Fox LM, Miksanek J, May NA, Scharf L, Lockridge JL, Veerapen N, Besra GS, Adams EJ, Hudson AW, Gumperz JE. Expression of CD1c enhances human invariant NKT cell activation by a-GalCer. Cancer Immun. 2013; 13:9. View in: PubMed

  42. Li NS, Scharf L, Adams EJ, Piccirilli JA. Highly stereocontrolled total synthesis of ß-D-mannosyl phosphomycoketide: a natural product from Mycobacterium tuberculosis. J Org Chem. 2013 Jun 21; 78(12):5970-86. View in: PubMed

  43. López-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):E1771-8. View in: PubMed

  44. Ly D, Kasmar AG, Cheng TY, de Jong A, Huang S, Roy S, Bhatt A, van Summeren RP, Altman JD, Jacobs WR, Adams EJ, Minnaard AJ, Porcelli SA, Moody DB. CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens. J Exp Med. 2013 Apr 08; 210(4):729-41. View in: PubMed

  45. Adams EJ, Luoma AM. The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules. Annu Rev Immunol. 2013; 31:529-61. View in: PubMed

  46. Adams EJ. Diverse antigen presentation by the Group 1 CD1 molecule, CD1c. Mol Immunol. 2013 Sep; 55(2):182-5. View in: PubMed

  47. López-Sagaseta J, Kung JE, Savage PB, Gumperz J, Adams EJ. The molecular basis for recognition of CD1d/a-galactosylceramide by a human non-Va24 T cell receptor. PLoS Biol. 2012; 10(10):e1001412. View in: PubMed

  48. Adams EJ, Luoma AM. The yin and yang of CD1d recognition. Nat Immunol. 2012 Sep; 13(9):814-5. View in: PubMed

  49. Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E, Bonneville M, Adams EJ. The molecular basis for modulation of human V?9Vd2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J Biol Chem. 2012 Sep 21; 287(39):32780-90. View in: PubMed

  50. Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vd1 TCR. Eur J Immunol. 2012 Sep; 42(9):2505-10. View in: PubMed

  51. Harly C, Guillaume Y, Nedellec S, Peigné CM, Mönkkönen H, Mönkkönen J, Li J, Kuball J, Adams EJ, Netzer S, Déchanet-Merville J, Léger A, Herrmann T, Breathnach R, Olive D, Bonneville M, Scotet E. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human ?d T-cell subset. Blood. 2012 Sep 13; 120(11):2269-79. View in: PubMed

  52. López-Sagaseta J, Sibener LV, Kung JE, Gumperz J, Adams EJ. Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor. EMBO J. 2012 Apr 18; 31(8):2047-59. View in: PubMed

  53. Sandstrom A, Scharf L, McRae G, Hawk AJ, Meredith SC, Adams EJ. ?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion. J Biol Chem. 2012 Feb 17; 287(8):6035-43. View in: PubMed

  54. Kazen AR, Adams EJ. Evolution of the V, D, and J gene segments used in the primate gammadelta T-cell receptor reveals a dichotomy of conservation and diversity. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):E332-40. View in: PubMed

  55. Adams EJ, López-Sagaseta J. The immutable recognition of CD1d. Immunity. 2011 Mar 25; 34(3):281-3. View in: PubMed

  56. Gleimer M, Wahl AR, Hickman HD, Abi-Rached L, Norman PJ, Guethlein LA, Hammond JA, Draghi M, Adams EJ, Juo S, Jalili R, Gharizadeh B, Ronaghi M, Garcia KC, Hildebrand WH, Parham P. Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires. J Immunol. 2011 Feb 01; 186(3):1575-88. View in: PubMed

  57. Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ. The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity. 2010 Dec 14; 33(6):853-62. View in: PubMed

  58. Older Aguilar AM, Guethlein LA, Adams EJ, Abi-Rached L, Moesta AK, Parham P. Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells. J Immunol. 2010 Oct 01; 185(7):4238-51. View in: PubMed

  59. Lodolce JP, Kolodziej LE, Rhee L, Kariuki SN, Franek BS, McGreal NM, Logsdon MF, Bartulis SJ, Perera MA, Ellis NA, Adams EJ, Hanauer SB, Jolly M, Niewold TB, Boone DL. African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. J Immunol. 2010 Jun 15; 184(12):7001-9. View in: PubMed

  60. Verykokakis M, Boos MD, Bendelac A, Adams EJ, Pereira P, Kee BL. Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells. PLoS One. 2010 Feb 19; 5(2):e9303. View in: PubMed

  61. Fox LM, Cox DG, Lockridge JL, Wang X, Chen X, Scharf L, Trott DL, Ndonye RM, Veerapen N, Besra GS, Howell AR, Cook ME, Adams EJ, Hildebrand WH, Gumperz JE. Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biol. 2009 Oct; 7(10):e1000228. View in: PubMed

  62. Adams EJ, Strop P, Shin S, Chien YH, Garcia KC. An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nat Immunol. 2008 Jul; 9(7):777-84. View in: PubMed

  63. Adams EJ, Juo ZS, Venook RT, Boulanger MJ, Arase H, Lanier LL, Garcia KC. Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10128-33. View in: PubMed

  64. Maynard J, Adams EJ, Krogsgaard M, Petersson K, Liu CW, Garcia KC. High-level bacterial secretion of single-chain alphabeta T-cell receptors. J Immunol Methods. 2005 Nov 30; 306(1-2):51-67. View in: PubMed

  65. Garcia KC, Adams EJ. How the T cell receptor sees antigen--a structural view. Cell. 2005 Aug 12; 122(3):333-6. View in: PubMed

  66. Shin S, El-Diwany R, Schaffert S, Adams EJ, Garcia KC, Pereira P, Chien YH. Antigen recognition determinants of gammadelta T cell receptors. Science. 2005 Apr 08; 308(5719):252-5. View in: PubMed

  67. Adams EJ, Chien YH, Garcia KC. Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science. 2005 Apr 08; 308(5719):227-31. View in: PubMed

  68. Maynard J, Petersson K, Wilson DH, Adams EJ, Blondelle SE, Boulanger MJ, Wilson DB, Garcia KC. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity. 2005 Jan; 22(1):81-92. View in: PubMed

  69. Krogsgaard M, Prado N, Adams EJ, He XL, Chow DC, Wilson DB, Garcia KC, Davis MM. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell. 2003 Dec; 12(6):1367-78. View in: PubMed

  70. Adams EJ, Garcia KC. A T cell receptor goes public. Structure. 2002 Nov; 10(11):1468-9. View in: PubMed

  71. Guethlein LA, Flodin LR, Adams EJ, Parham P. NK cell receptors of the orangutan (Pongo pygmaeus): a pivotal species for tracking the coevolution of killer cell Ig-like receptors with MHC-C. J Immunol. 2002 Jul 01; 169(1):220-9. View in: PubMed

  72. Geller R, Adams EJ, Guethlein LA, Little AM, Madrigal JA, Parham P. Linkage of Patr-AL to Patr-A and- B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes). Immunogenetics. 2002 Jun; 54(3):212-5. View in: PubMed

  73. Adams EJ, Parham P. Species-specific evolution of MHC class I genes in the higher primates. Immunol Rev. 2001 Oct; 183:41-64. View in: PubMed

  74. Adams EJ, Cooper S, Parham P. A novel, nonclassical MHC class I molecule specific to the common chimpanzee. J Immunol. 2001 Oct 01; 167(7):3858-69. View in: PubMed

  75. Adams EJ, Parham P. Genomic analysis of common chimpanzee major histocompatibility complex class I genes. Immunogenetics. 2001 Apr; 53(3):200-8. View in: PubMed

  76. Rajalingam R, Hong M, Adams EJ, Shum BP, Guethlein LA, Parham P. Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes. J Exp Med. 2001 Jan 01; 193(1):135-46. View in: PubMed

  77. Adams EJ, Cooper S, Thomson G, Parham P. Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes. Immunogenetics. 2000 May; 51(6):410-24. View in: PubMed

  78. Adams EJ, Thomson G, Parham P. Evidence for an HLA-C-like locus in the orangutan Pongo pygmaeus. Immunogenetics. 1999 Sep; 49(10):865-71. View in: PubMed

  79. Cooper S, Erickson AL, Adams EJ, Kansopon J, Weiner AJ, Chien DY, Houghton M, Parham P, Walker CM. Analysis of a successful immune response against hepatitis C virus. Immunity. 1999 Apr; 10(4):439-49. View in: PubMed

  80. Dixon B, Shum B, Adams EJ, Magor KE, Hedrick RP, Muir DG, Parham P. CK-1, a putative chemokine of rainbow trout (Oncorhynchus mykiss). Immunol Rev. 1998 Dec; 166:341-8. View in: PubMed

  81. Cooper S, Adams EJ, Wells RS, Walker CM, Parham P. A major histocompatibility complex class I allele shared by two species of chimpanzee. Immunogenetics. 1998; 47(3):212-7. View in: PubMed

  82. Parham P, Arnett KL, Adams EJ, Little AM, Tees K, Barber LD, Marsh SG, Ohta T, Markow T, Petzl-Erler ML. Episodic evolution and turnover of HLA-B in the indigenous human populations of the Americas. Tissue Antigens. 1997 Sep; 50(3):219-32. View in: PubMed

  83. Magor KE, Taylor EJ, Shen SY, Martinez-Naves E, Valiante NM, Wells RS, Gumperz JE, Adams EJ, Little AM, Williams F, Middleton D, Gao X, McCluskey J, Parham P, Lienert-Weidenbach K. Natural inactivation of a common HLA allele (A*2402) has occurred on at least three separate occasions. J Immunol. 1997 Jun 01; 158(11):5242-50. View in: PubMed

  84. Tzeng CM, Adams EJ, Gumperz JE, Percival L, Wells RS, Parham P, Barber LD. Peptides bound endogenously by HLA-Cw*0304 expressed in LCL 721.221 cells include a peptide derived from HLA-E. Tissue Antigens. 1996 Oct; 48(4 Pt 1):325-8. View in: PubMed

  85. Chandanayingyong D, Adams EJ, Arnett KL, Hildebrand WH, Parham P, Lau M. The presence of HLA-A*2403 and HLA-B*1512 on the same haplotype in a Thai family. Tissue Antigens. 1996 May; 47(5):426-7. View in: PubMed

  86. Arnett KL, Adams EJ, Gumperz JE, Darke C, Marsh SG, Gelsthorpe K, Parham P. Expression of an unusual Bw4 epitope by a subtype of HLA-B8 [B*0802]. Tissue Antigens. 1995 Oct; 46(4):316-21. View in: PubMed

  87. Parham P, Adams EJ, Arnett KL. The origins of HLA-A,B,C polymorphism. Immunol Rev. 1995 Feb; 143:141-80. View in: PubMed

  88. Parham P, Arnett KL, Adams EJ, Barber LD, Domena JD, Stewart D, Hildebrand WH, Little AM. The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B alleles. Tissue Antigens. 1994 May; 43(5):302-13. View in: PubMed
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