Cassandra Hayne | Biochemistry and Molecular Biophysics

Keywords

Biochemistry, RNA, Neurodegenerative Diseases, Neurodevelopmental Diseases, Cell and Molecular Biology, Cryo-Electron Microscopy, tRNA, RNA Processing, Post-Transcriptional

Education

National Institute of Environmental Health Sciences, RTP, NC, Postdoctoral Fellowship Biochemistry & Structural Biology 2022
University of North Carolina at Chapel Hill, Chapel Hill, NC, Ph.D. Biochemistry 2017
University of Northern Iowa, Cedar Falls, IA, B.A./B.S. Biochemistry & Biology 2011

Awards & Honors

2013 - Graduate Research Fellowship NSF
2021 - MOSAIC K99/R00 NIGMS/NIH

Publications

Recent insights into the structure, function, and regulation of the eukaryotic transfer RNA splicing endonuclease complex. Wiley Interdiscip Rev RNA. 2022 09; 13(5):e1717. View in: PubMed
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun. 2021 01 27; 12(1):636. View in: PubMed
Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage. Nucleic Acids Res. 2020 08 20; 48(14):7609-7622. View in: PubMed
We FRET so You Don't Have To: New Models of the Lipoprotein Lipase Dimer. Biochemistry. 2018 01 16; 57(2):241-254. View in: PubMed
Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake. Biochemistry. 2017 01 24; 56(3):525-533. View in: PubMed
Modulation of the Activity of Mycobacterium tuberculosis LipY by Its PE Domain. PLoS One. 2015; 10(8):e0135447. View in: PubMed