Robert J. Keenan, PhD

We study the molecular mechanisms underlying membrane protein biogenesis and quality control using biochemical, structural and cell biology approaches.

UCSF
San Francisco, CA
Postdoc - Biochemistry and Biophysics
1999

UCSF
San Francisco, CA
PHD - Biochemistry and Biophysics
1998

Bates College
Lewiston, ME
BS - Biology and Chemistry
1990

Substrate-driven assembly of a translocon for multipass membrane proteins.
Substrate-driven assembly of a translocon for multipass membrane proteins. Nature. 2022 11; 611(7934):167-172.
PMID: 36261522

Mechanism of an intramembrane chaperone for multipass membrane proteins.
Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature. 2022 11; 611(7934):161-166.
PMID: 36261528

The mechanisms of integral membrane protein biogenesis.
The mechanisms of integral membrane protein biogenesis. Nat Rev Mol Cell Biol. 2022 02; 23(2):107-124.
PMID: 34556847

An ER translocon for multi-pass membrane protein biogenesis.
An ER translocon for multi-pass membrane protein biogenesis. Elife. 2020 08 21; 9.
PMID: 32820719

The architecture of EMC reveals a path for membrane protein insertion.
The architecture of EMC reveals a path for membrane protein insertion. Elife. 2020 05 27; 9.
PMID: 32459176

Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer.
Spiess PE, Greene J, Keenan RJ, Paculdo D, Letson GD, Peabody JW. Meeting the challenge of the 2019 novel coronavirus disease in patients with cancer. Cancer. 2020 Jul 15; 126(14):3174-3175.
PMID: 32324273

A structural perspective on tail-anchored protein biogenesis by the GET pathway.
A structural perspective on tail-anchored protein biogenesis by the GET pathway. Curr Opin Struct Biol. 2018 08; 51:195-202.
PMID: 30173121

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum.
Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum. Cell Rep. 2017 12 26; 21(13):3708-3716.
PMID: 29281821

Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer.
Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer. Cell Rep. 2017 Sep 05; 20(10):2287-2293.
PMID: 28877464

Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins.
Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins. Mol Cell. 2017 Jul 20; 67(2):194-202.e6.
PMID: 28712723

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