Faculty

Eduardo Perozo, PhD

A designer pore-blocking peptide reveals an electrostatic complementation mechanism for the inhibition-resistant Kv1.5 channel.
A designer pore-blocking peptide reveals an electrostatic complementation mechanism for the inhibition-resistant Kv1.5 channel. Sci Adv. 2026 Sep 04; 12(36):eaef6020.
PMID: 42696590

Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.
Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating. Proc Natl Acad Sci U S A. 2026 Feb 24; 123(8):e2512532123.
PMID: 41701836

The BK channel-NS1619 agonist complex reveals molecular insights into allosteric activation gating.
The BK channel-NS1619 agonist complex reveals molecular insights into allosteric activation gating. Proc Natl Acad Sci U S A. 2026 Feb 03; 123(5):e2507707123.
PMID: 41591909

Structural Mechanism of Prestin-Membrane Mechanotransduction.
Structural Mechanism of Prestin-Membrane Mechanotransduction. bioRxiv. 2025 Dec 31.
PMID: 41502949

Closed state structure of the pore revealed by uncoupled Shaker K+ channel.
Closed state structure of the pore revealed by uncoupled Shaker K+ channel. Nat Commun. 2025 Nov 19; 16(1):10180.
PMID: 41261088

The Closed State of the Shaker Potassium Channel and the Mechanism of Voltage Activation.
The Closed State of the Shaker Potassium Channel and the Mechanism of Voltage Activation. bioRxiv. 2025 Nov 14.
PMID: 41292991

Structural basis of voltage-dependent gating in BK channels.
Structural basis of voltage-dependent gating in BK channels. Nat Commun. 2025 Jul 01; 16(1):5846.
PMID: 40593533

Closed State Structure of the Pore Revealed by Uncoupled Shaker K+ Channel.
Closed State Structure of the Pore Revealed by Uncoupled Shaker K+ Channel. Res Sq. 2025 May 09.
PMID: 40386396

The BK channel-NS1619 agonist complex reveals molecular insights on allosteric activation gating.
The BK channel-NS1619 agonist complex reveals molecular insights on allosteric activation gating. bioRxiv. 2025 Apr 01.
PMID: 40235977

Closed State Structure of the Pore Revealed by Uncoupled Shaker K+ Channel.
Closed State Structure of the Pore Revealed by Uncoupled Shaker K+ Channel. bioRxiv. 2025 Mar 17.
PMID: 40166146

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