Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.
Harvard
Cambridge
Postdoc - Chemical Biology
2002
MIT
Cambridge
Ph.D. - Chemistry
2000
University of Sci. & Tech. China
Hefei/China
B.S. - Chemistry
1994
Pseudouridine Detection and Quantification Using Bisulfite Incorporation Hindered Ligation.
Pseudouridine Detection and Quantification Using Bisulfite Incorporation Hindered Ligation. ACS Chem Biol. 2024 Jul 16.
PMID: 39014961
LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA.
LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA. Genome Biol. 2024 06 14; 25(1):157.
PMID: 38877540
Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis.
Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis. Nat Commun. 2024 Jun 07; 15(1):4881.
PMID: 38849358
m6A RNA methylation regulates mitochondrial function.
m6A RNA methylation regulates mitochondrial function. Hum Mol Genet. 2024 May 18; 33(11):969-980.
PMID: 38483349
Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance.
Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance. Clin Cancer Res. 2024 May 01.
PMID: 38691100
Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation.
Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation. Cell Rep. 2024 May 28; 43(5):114165.
PMID: 38691450
The YTHDF proteins display distinct cellular functions on m6A-modified RNA.
The YTHDF proteins display distinct cellular functions on m6A-modified RNA. Trends Biochem Sci. 2024 Jul; 49(7):611-621.
PMID: 38677920
Chemical manipulation of m1A mediates its detection in human tRNA.
Chemical manipulation of m1A mediates its detection in human tRNA. RNA. 2024 Apr 16; 30(5):548-559.
PMID: 38531647
5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer.
5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer. Gynecol Oncol. 2024 Mar; 182:82-90.
PMID: 38262243
KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.
KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions. Nat Biotechnol. 2024 Jan 18.
PMID: 38238480
ACS Chemical Biology Lectureship
2019
Paul Marks Prize in Cancer Research
2017
HHMI Investigator
2013