Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.
Harvard
Cambridge
Postdoc - Chemical Biology
2002
MIT
Cambridge
Ph.D. - Chemistry
2000
University of Sci. & Tech. China
Hefei/China
B.S. - Chemistry
1994
IGF2BP3 promotes mRNA degradation through internal m7G modification.
IGF2BP3 promotes mRNA degradation through internal m7G modification. Nat Commun. 2024 Aug 28; 15(1):7421.
PMID: 39198433
RNA interacts with topoisomerase I to adjust DNA topology.
RNA interacts with topoisomerase I to adjust DNA topology. Mol Cell. 2024 Aug 19.
PMID: 39173639
PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression.
PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression. Nat Commun. 2024 Aug 13; 15(1):6947.
PMID: 39138174
Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq.
Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq. Nat Commun. 2024 Aug 10; 15(1):6852.
PMID: 39127768
YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges.
YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges. bioRxiv. 2024 Aug 09.
PMID: 39149343
Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures.
Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures. Cancer Res Commun. 2024 Aug 01; 4(8):2255-2266.
PMID: 39099200
Pseudouridine Detection and Quantification Using Bisulfite Incorporation Hindered Ligation.
Pseudouridine Detection and Quantification Using Bisulfite Incorporation Hindered Ligation. ACS Chem Biol. 2024 Aug 16; 19(8):1813-1819.
PMID: 39014961
LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA.
LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA. Genome Biol. 2024 06 14; 25(1):157.
PMID: 38877540
Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis.
Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis. Nat Commun. 2024 Jun 07; 15(1):4881.
PMID: 38849358
m6A RNA methylation regulates mitochondrial function.
m6A RNA methylation regulates mitochondrial function. Hum Mol Genet. 2024 May 18; 33(11):969-980.
PMID: 38483349
ACS Chemical Biology Lectureship
2019
Paul Marks Prize in Cancer Research
2017
HHMI Investigator
2013